Several studies have demonstrated a dramatic increase in sperm DNA fragmentation in obese men, and this can lead to a significant reduction in sperm quality. In addition, there may be an increase in the miscarriage rate for men with high-level fragmented DNA damage. Increased sperm DNA fragmentation due to oxidative stress may be due to several factors: men over age 50; possibly cigarette smoke, excessive exposure to heat; obesity and numerous environmental toxins. Some of this sperm DNA fragmentation may be reversed.
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